Plx-4032 是一种小分子 B-Raf 抑制剂，可用于治疗恶性黑色素瘤。

PLX-4032 is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.

PLX-4032 and its related analogs are highly potent inhibitors of B-Raf activity, with 3-fold selectivity for the V600E mutation over the wild-type kinase.?In preclinical models, PLX-4032 and its analogs inhibited the growth of BRAFV600E-positive melanoma cell lines both in vitro and in vivo[1].

1029872-54-5

C23H18ClF2N3O3S

489.92

Vemurafenib;维罗非尼

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years