2,5-Dihydroxyacetophenone 是从熟地黄中分离出的一种天然产物，通过阻断ERK1/2和NF-κB信号通路，抑制活化巨噬细胞中炎症介质的产生。

1. 2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. 3. 2, 5-Dihydroxyacetophenone has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions. 4. 2, 5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models.

490-78-8

C8H8O3

152.149

Acetylhydroquinone;2-5-dihydroxyacetophenone;DHAP;Quinacetophenone;2 '，5'-二羟基苯乙酮;2-Acetylhydroquinone;2,5-二羟基苯乙酮

DMSO:28 mg/mL(184 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years