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LM 10
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LM 10图片
CAS NO:1316695-35-8
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
LM 10 是色氨酸 2,3-双加氧酶 (TDO) 的有效抑制剂。色氨酸 2,3-双加氧酶 (TDO) 是一种无关的肝酶,它也沿着犬尿氨酸途径降解色氨酸。 LM 10 具有研究癌症疾病的潜力。
Cas No.1316695-35-8
别名(E)-3-(2-(1H-四氮唑-5-基)乙烯基)-6-氟-1H-吲哚
Canonical SMILESFC1=CC=C2C(NC=C2/C=C/C3=NN=NN3)=C1
分子式C11H8FN5
分子量229.21
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. Reduces growth of TDO-expressing P815 mastocytoma tumors in mice. Orally bioavailable.

Pilotte et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.U.S.A. 109 2497 PMID:22308364 |Dolusić et al (2011) Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J.Med.Chem. 54 5320 PMID:21726069