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Mc-Val-Cit-PAB-Cl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mc-Val-Cit-PAB-Cl图片
CAS NO:1639351-92-0
包装:100mg
市场价:18000元

产品介绍
Mc-Val-Cit-PAB-Cl是一种可降解的ADClinker,可用于连接MMAE和抗体,从而形成抗体-MC-vc-MMAE(如anti-CD22-MC-VC-PABC-MMAE,对BJAB和WSU具有细胞毒性,IC50分别为3.3nM和0.95nM)。
Cas No.1639351-92-0
Canonical SMILESO=C(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(CCl)C=C2)=O)=O)=O)C=CC1=O
分子式C28H39ClN6O6
分子量591.1
储存条件-20℃, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

[1]. Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.