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m-PEG5-NHS ester
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG5-NHS ester图片
CAS NO:874208-94-3
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
m-PEG5-NHSester是一种基于PEG的PROTAClinker,可用于PROTAC的合成。
Cas No.874208-94-3
别名甲基-四聚乙二醇-丙烯酸琥珀酰亚胺酯
Canonical SMILESCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
分子式C16H27NO9
分子量377.39
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.