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m-PEG5-SH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG5-SH图片
CAS NO:524030-00-0
包装与价格:
包装价格(元)
100mg电议
500mg电议

产品介绍
m-PEG5-SH是一种PROTAClinker,属于PEG类。可用于合成PROTAC分子。
Cas No.524030-00-0
别名3,6,9,12,15-五氧杂十六烷-1-硫醇
Canonical SMILESCOCCOCCOCCOCCOCCS
分子式C11H24O5S
分子量268.37
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562