BI-3406 是一种可口服、高效且选择性的 KRas-SOS1 抑制剂，具有抗癌活性。它有效减少 GTP 加载的 KRas 的形成，抑制MAPK信号通路。它还抑制KRas与SOS1之间相互作用，IC50为 6 nM。

BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.

2230836-55-0

C23H25F3N4O3

462.46

Ethanol:100 mg/mL (216.23 mM),Need ultrasonic
DMSO:95mg/ml (205.42 Mm),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years