HJC0197 是Epac1(cAMP 1 直接激活的交换蛋白) 和Epac2 拮抗剂，其对Epac2 的IC50值为5.9 μM。它在等浓度 cAMP 存在下能够降低 Epac1 介导的 Rap1-GDP 交换活性。它能够选择性阻断 cAMP 诱导的 Epac 活化。

HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).

In the presence of an equal concentration of cAMP, HJC0197 (25 μM) also inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM.

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C19H21N3OS

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