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Compound 3344 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Compound 3344 hydrochloride图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品名称
4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base)
Compound 3344 hydrochloride (2368246-78-8 free base)
产品介绍
Compound 3344 hydrochloride 是 KRas 效应相互作用的抑制剂,亲和力为 126nm。

产品描述

Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.

体外活性

In vitro competition studies of 3344 hydrochloride binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 hydrochloride binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 hydrochloride binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 hydrochloride was used for validation of the BRET2 toolbox for RAS-effector PPI inhibitors.

Cas No.

T9184L

分子式

C24H27ClN2O3

分子量

426.94

别名

4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base);Compound 3344 hydrochloride (2368246-78-8 free base)

储存和溶解度

DMSO:60 mg/ml (140.53 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years