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Cephradine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cephradine图片
CAS NO:38821-53-3
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
Anspor
SQ-11436
头孢拉定
Velosef
Sefril
Cephradin
产品介绍
Cephradine是广谱口服活性头孢菌素。它对革兰氏阳性和革兰氏阴性病原体都有活性。它已用于泌尿生殖系统、胃肠道和呼吸道感染以及皮肤和软组织感染的研究。它通过直接抑制TOPK抑制太阳紫外线诱导的皮肤炎症。

产品描述

Cephradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.

体内活性

Cephradine has a low order of acute, subacute, and chronic oral toxicity, and acute and subacute parenteral toxicity. After daily intravenous doses of cephradine has been given to monkeys for 2 weeks, these animals show no signs of nephrotoxicity. Cephradine does not induce any teratogenic changes in the offspring of either mice or rats. The route of administration has been a determinant in the choice of a cephalosporin antibiotic. It is a distinct therapeutic advantage that a single cephalosporin antibiotic, cephradine, may be used in both oral and parenteral preparations[2].

细胞实验

Cells Are seeded in six-well culture plates (9.6 cm2, growth area) at a density of 105 cells/cm2. At 2 days postseeding, the medium is removed and cells are washed twice with pH 6.0 uptake buffer. Independent studies are performed for each drug solution at 1 mg/mL made in pH 6.0 uptake buffer. At each time point (10, 20, 30, 45, 60, 90 min), drug solution is removed and cells are washed three times with ice-cold pH 6.0 uptake buffer. One milliliter of Milli-Q water is added to each well and incubated for 30 min at 25 °C. Cells are harvested and sonicated for 1-2 min. ZnSO4 solution (8%, 200 mL) is added to the cell lysate, vortexed rigorously, and centrifuged for 5 min at 3000 rpm. After filtration of the supernatant through a membrane filter (0.45 mm), samples are analyzed by HPLC. (Only for Reference)

Cas No.

38821-53-3

分子式

C16H19N3O4S

分子量

349.41

别名

Anspor;SQ-11436;头孢拉定;Velosef;Sefril;Cephradin

储存和溶解度

DMSO:3.6 mg/mL (10.30 mM)
H2O:8.33 mg/mL (23.84 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years