SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。

SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.

SMIP004 reduces the levels of positive cell cycle regulators upregulates cyclin-dependent kinase inhibitors. It also causes G1 arrest, inhibition of colony formation in soft agar, and cell death [2].

In SCID mice, SMIP004 effectively inhibits the growth of prostate and breast cancer xenografts [2].

143360-00-3

C13H19NO

205.3

DMSO:100 mg/mL (487.09 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years