GS-143 是选择性的IκBα泛素化抑制剂，抑制 SCFβTrCP1介导的IκBα泛素化作用，IC50=5.2 μM。GS143 抑制NF-Κb的活化和靶基因的转录，并且不抑制蛋白酶体的特性，并具有抗哮喘作用。

GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect

916232-21-8

C28H19FN2O4

466.46

GS 143;GS-143

DMSO:40 mg/mL (85.75 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years