Cladribine 是一种嘌呤核苷类似物，是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂，可阻断受损 DNA 的修复。它可抑制 DNA 甲基化，具有抗淋巴瘤活性，可研究血液恶性肿瘤和多发性硬化。

Cladribine, an adenosine deaminase inhibitor, is utilized in the treatment of lymphoproliferative diseases.

在成年斑马鱼中,腹腔注射Cladribine（0.7-3.5 mM ）,能够抑制RBC ATP浓度水平.

在原代肥大细胞（MC）和MC系HMC-1中,Cladribine抑制细胞生长。在CD14 +单核细胞以及CD4 +和CD8 + T淋巴细胞中,Cladribine降低细胞迁移能力。在U266,RPMI8226和MM1.S细胞中,Cladribine以剂量依赖性方式抑制细胞增殖。

The non-radioactive cell proliferation kit is used to determine cell viability. In brief, Human MM cell line U266, RPMI8226 and MM1.S are seeded onto 96-well plates with either 0.1 mL complete medium (5% FBS) as control, or 0.1 mL of the same medium containing a series of doses of cladribine, and incubated for 72 hours. After reading all wells at 490 nm with a micro-plate reader, the percentages of surviving cells from each group relative to controls, defined as 100% survival, are determined by reduction of MTS.(Only for Reference)

4291-63-8

C10H12ClN5O3

285.69

克拉屈滨;2CdA;CldAdo;2-Chloro-2′-deoxyadenosine;2-chlorodeoxyadenosine

Ethanol:<1 mgml
H2O:<1 mgml
DMSO:53 mg/mL (185.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years