Diethyl-pythiDC 是一种胶原蛋白脯氨酰 4-羟化酶抑制剂。

Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.

In MDA-MB-231 cells, Diethyl-pythiDC inhibits CP4H activity in cultured cells at concentrations that do not cause iron deficiency. None of the esterified Diethyl-pythiDC exhibited cytotoxic activity at high micromolar concentrations. Cells treated with dihydroxybenzoate demonstrate a strong iron-deficient phenotype. In contrast, cells treated with Diethyl-pythiDC appear to be normal at concentrations as high as 500 μM. Treatment with Diethyl-pythiDC and low levels of diethyl pyimDC does not affect the level of TfR, HIF-1α, or ferritin[1].

1821370-70-0

C14H14N2O4S

306.34

DMSO:33 mg/mL (107.72 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years