p-Ethynylphenylalanine hydrochloride 是一种高效的、可逆的、选择性的、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其Ki=32.6 μM。

p-Ethynylphenylalanine hydrochloride is a novel, potent and specific inhibitor of TPH[1]. The potential for p-Ethynylphenylalanine hydrochloride to inhibit selectively and reversibly the biosynthesis of serotonin may contribute to the characterization of the role of serotonin in behavioral and physiological activities[1].

p-Ethynylphenylalanine hydrochloride was demonstrated to inhibit competitively and reversibly TPH in vitro (Ki = 32.6 +/- 6.2 microM vs. tryptophan)[1].

Administration of p-Ethynylphenylalanine hydrochloride (30 mg/kg) to rats produced a 95 +/- 5% decrease in TPH activity in brain homogenates and a concomitant decrease in serotonin and 5-hydroxyindole-3-acetic acid levels (85%) at 24 h after injection[1].

188640-63-3

C11H12ClNO2

225.67

p-Ethynylphenylalanine hydrochloride(278605-15-5 free base);4-Ethynyl-L-phenylalanine HCL

H2O:12 mg/mL (53.17 mM),Need ultrasonic
DMSO:99 mg/mL (438.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years