ZamicaSTAT 是多巴胺 β-羟化酶 (DBH) 抑制剂，可透过血脑屏障引起中枢和周边效应，具有降血压作用。它也是一种浓度依赖性的双重P-gp和BCRP抑制剂，IC50值分别为 73.8 和 17.0 μM。

Zamicastat is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).

In the Dahl SS rat, Zamicastat (10, 30 and 100 mg/kg/day; oral bolus, 7 days) is tested acutely against salt-induced hypertension. Zamicastat produces a dose-dependent decrease in blood pressure[2].

1080028-80-3

C21H21F2N3OS

401.47

BIA 5-1058

DMSO:150 mg/mL (373.63 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years