ACT-678689 是一种色氨酸羟化酶 (TPH) 抑制剂，IC50=8 nM。

ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].

TPH comprises two isoforms: TPH1 and TPH2. TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets[1]. TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS).

1783256-96-1

C23H22ClFN6O4S2

565.04

Compound Example 1.53.4

DMSO:120 mg/mL (212.37 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years