TelotriSTAT ethyl 是一种口服具有活力的色氨酸羟化酶抑制剂，可抑制血清素的产生。

Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. However, Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT) nor alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2]. Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease.

1033805-22-9

C27H26ClF3N6O3

574.98

LX1606

DMSO:98.5 mg/mL (171.31mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years