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CP-532623
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CP-532623图片
CAS NO:261947-38-0
包装:10 mg
市场价:7000元

产品介绍

产品描述

CP-532623, a close structural analog of Torcetrapib, is a CETP inhibitor with highly lipophilic properties. It elevates high-density lipoprotein cholesterol.

体外活性

CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons. CP-532623 is highly lymphatically transported (28% of the dose). However, it lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions. But, it has poorly related to solubility in mixtures of lipoprotein core and/or surface lipids [2].

体内活性

CP-532623 (50 mg; p.o.; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively) [3].

Cas No.

261947-38-0

分子式

C27H27F9N2O3

分子量

598.5

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years