(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and is a potent agonist of GPR88 receptor(EC50 of 3 nM and 603 nM in cell-free assay and in cell assay).

(1R,2R)-2-PCCA is a potent agonist of GPR88 receptor(EC50 of 3 nM in cell-free assay, and 603 nM in cell assay)[1][2]. (1R,2R)-2-PCCA inhibits GPR88-mediated cAMP production through a Gαi-coupled pathway, with an EC50 of 56 nM in HEK293 cells stably expressing the human GPR88 receptor and the GloSensor-22F cAMP construct[2].

1609563-71-4

C30H39Cl2N3O

528.56

(1R,2R)-2-PCCA(hydrochloride)

DMSO:50 mg/mL (94.60 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years