CAS NO: | 1715934-43-2 |
包装: | 10mg |
市场价: | 3778元 |
Cas No. | 1715934-43-2 |
Canonical SMILES | CC2=C(C3=CC=CC(S(N(C)C)(=O)=O)=C3)N1N=C(Cl)C=C(NCCNC(C)=O)C1=N2 |
分子式 | C19H23ClN6O3S |
分子量 | 450.94 |
溶解度 | Soluble in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays. Mejdrová et al (2015) Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action. J.Med.Chem. 58 3767 PMID:25897704 |