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GA3-AM
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GA3-AM图片
CAS NO:1373154-68-7
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
GA3-AM 是植物激素赤霉酸的细胞渗透性类似物,可作为化学二聚体或二聚化的化学诱导剂。
Cas No.1373154-68-7
Canonical SMILES[H][C@@]12[C@@](C[C@@]3(O)CC2)(CC3=C)[C@@H](C(OCOC(C)=O)=O)[C@]4([H])[C@@]5(C)[C@@H](O)C=C[C@]41OC5=O
分子式C22H26O8
分子量418.44
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Gibberellin-analog (GA3) chemical dimerizer; induces rapid dimerization of GAIs and GID1. GA3-AM crosses the plasma membrane, is cleaved by cytosolic esterase releasing GA3, which then binds GID1- this complex then in turn forms a complex with GAI; this system works on a timescale of seconds (EC50 = 310 nM). GA3 and rapamycin chemically inducible dimerization systems are orthogonal. Cell permeable.

Lin et al (2013) Rapidly reversible manipulation of molecular activities using dual chemical dimerizers Angew.Chem.Int.Ed.Engl. 52 6450 PMID:23649661 |Miyamoto et al (2012) Rapid and orthogonal logic gating with a gibberellin-induced dimerization system Nat.Chem.Biol. 8 465 PMID:22446836