PGS-IN-1是一种前列腺素合成酶抑制剂,IC50=0.28 μM。它也可抑制5-脂肪氧合酶的活性,IC50=1.05 μM。
产品描述
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).
体外活性
PGS-IN-1 is the trans isomer of the synthesized α-benzulidene-γ-butyrolactone. PGS-IN-1 exhibits potent anti-inflammatory and PGS inhibitory activity with IC50 of 0.28 μM[1]. PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase with IC50 of 1.05 μM[1].
Cas No.
102271-49-8
分子式
C19H26O3
分子量
302.41
别名
KME-4
储存和溶解度
DMSO:55 mg/ml (181.87 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years