BI-0115 是LOX-1的选择性抑制剂，其IC50值为 5.4?μM，可以阻止细胞摄取氧化低密度脂蛋白。它通过形成同源二聚体配体结合域的二聚体来触发受体抑制。

BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.

4929-23-1

C15H14ClN3O

287.75

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years