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CID 2011756
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CID 2011756图片
CAS NO:638156-11-3
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CID2011756
CID-2011756
产品介绍
CID2011756 是一种具有抗肿瘤活性的ATP 竞争性广谱PKD抑制剂,对 PKD1 的IC50值为 3.2 μM,在细胞中对 PKD2 和 PKD3 的IC50值分别为 0.6 和 0.7 μM。

产品描述

CID-2011756 is an ATP-competitive and specific PKD1 inhibitor.

激酶实验

Ub-PLA2 assay: Recombinant enzymes in 20 mM Tris-HCl, pH 8.0, 2 mM CaCl2 and 2 mM β-mercaptoethanol (DUB assay buffer) are preincubated with single doses or dose ranges of PR-619 or P22077 for 30 minutes in a 96 well plate before the addition of Ub-PLA2 and NBD C6-HPC. The liberation of a fluorescent product within the linear range of the assay is monitored at room temperature using a fluorescence plate reader. Vehicle (2%(v/v) DMSO) and 10 mM N-ethylmaleimide are included as controls. Where ≥60% inhibition is observed, EC50 values are determined using a sigmoidal dose response equation.

Cas No.

638156-11-3

分子式

C22H21ClN2O3

分子量

396.87

别名

CID2011756;CID-2011756

储存和溶解度

DMSO:19.8 mg/mL(50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years