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YM-244769 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YM-244769 dihydrochloride图片
CAS NO:1780390-65-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
YM-244769 dihydrochloride 是一种有效的 Na+/Ca2+ exchange 3 (NCX3) 抑制剂,IC50 为 18 nM。 YM-244769 dihydrochloride 对神经元和肾脏具有有效的保护作用。

产品描述

YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys.

体外活性

YM-244769 dihydrochloride (0.3 or 1 μM) efficiently suppresses the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense (i.e., SH-SY5Y cells primarily expressing NCX3) more than in those treated with NCX3 antisense (i.e., SH-SY5Y cells primarily expressing NCX1). YM-244769 dihydrochloride (0.003-1 μM) inhibits the initial rates of 45 Ca 2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC 50 values of 68±2.9, 96±3.5, and 18±1.0 nM, respectively, indicating that YM-244769 dihydrochloride is approximately four to five times more selective to NCX3 than other isoforms[1].

Cas No.

1780390-65-9

分子式

C26H24Cl2FN3O3

分子量

516.39

储存和溶解度

DMSO:95 mg/mL (183.97 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years