Thiorphan 是选择性Neprilysin抑制剂 (IC50:6.9 nM) 。

Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).

Thiorphan reduces increases in gastric acid output induced by pentagastrin by 64% in rats when administered intracerebroventricularly at a dose of 50 μg, but not when administered intravenously at doses of 1.7 and 17 mg/kg[1]

76721-89-6

C12H15NO3S

253.32

DMSO:30mg/ml(118.4 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years