您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Triethylene glycol bis(p-toluenesulfonate)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Triethylene glycol bis(p-toluenesulfonate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Triethylene glycol bis(p-toluenesulfonate)图片
CAS NO:19249-03-7
包装:500mg
市场价:450元

产品介绍
Triethyleneglycolbis(p-toluenesulfonate)是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
Cas No.19249-03-7
别名三乙烯基二醇,Bis-Tos-PEG3
Canonical SMILESCC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOS(=O)(=O)C1=CC=C(C)C=C1
分子式C20H26O8S2
分子量458.54
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.