Sodium dichloroacetate 是癌细胞线粒体中的一种代谢调节剂,具有抗癌活性。它抑制丙酮酸脱氢酶激酶,从而导致肿瘤微环境中的乳酸减少。它增加活性氧的产生并促进癌细胞凋亡,还可作为NKCC抑制剂。
产品描述
Dichloroacetate, a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.
Cas No.
2156-56-1
分子式
C2HCl2NaO2
分子量
150.92
别名
bichloroacetic acid;Sodium Dichloroacetate;BCA;DCA;二氯乙酸钠;Sodium dichloroacetate (DCA);二氯醋酸酯
储存和溶解度
DMSO:15.1 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years