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8-iso Prostaglandin F2α-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
8-iso Prostaglandin F2α-d4图片
CAS NO:211105-40-7
包装与价格：
包装价格(元)
25 μg电议
50 μg电议
100 μg电议
500 μg电议

产品介绍
An internal standard for the quantification of 8iso prostaglandin F2α
Cas No.211105-40-7
Canonical SMILESO[C@@H]1[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@H](O)CCCCC)[C@H](O)C1
分子式C20H30D4O5
分子量358.5
溶解度10 mM Na2CO3: >6.5 mg/ml (from PGF2a),DMF: >100 mg/ml (from PGF2a),DMSO: >100 mg/ml (from PGF2a),Ethanol: >100 mg/ml (from PGF2a),PBS pH 7.2: >10 mg/ml (from PGF2a)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

8-isoPGF2α-d4contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-isoPGF2αby GC-or LC-mass spectrometry. 8-isoProstaglandin F2α(8-isoPGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.1,2,3It circulates in human plasma in two distinct forms -esterified in LDL phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-isoPGF2αlevel of about 150 pg/ml in normal volunteers. In normal human urine, 8-isoPGF2αlevels are about 180-200 pg/mg of creatinine.1,28-isoPGF2αis a weak TP receptor agonist in vascular smooth muscle.4Conversely, 8-isoPGF2αinhibits platelet aggregation induced by U-46619 (10-6M) and I-BOP (3 x 10-7M) with IC50values of 1.6 x 10-6M and 1.8 x 10-6M, respectively.3

1.Morrow, J.D., Hill, K.E., Burk, R.F., et al.A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanismProc. Natl. Acad. Sci. U.S.A.87(23)9383-9387(1990) 2.Morrow, J.D., Harris, T.M., and Roberts, L.J., IINoncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoidsAnal. Biochem.184(1)1-10(1990) 3.Morrow, J.D., Minton, T.A., and Roberts, L.J., IIThe F2-isoprostane, 8-epi-prostaglandin F2α, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonistProstaglandins44(2)155-163(1992) 4.Kiriyama, M., Ushikubi, F., Kobayashi, T., et al.Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.122(2)217-224(1997)