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Carbaryl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carbaryl图片
CAS NO:63-25-2
包装:100mg
市场价:476元

产品介绍
甲萘威主要用作杀虫剂。
Cas No.63-25-2
别名甲萘威
Canonical SMILESO=C(NC)OC1=C2C(C=CC=C2)=CC=C1
分子式C12H11NO2
分子量201.2
溶解度Chloroform: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Carbaryl is a carbamate insecticide that inhibits acetylcholinesterase (AChE; IC50= 13.6 nM forA. gambiaeAChE2 expressed in Sf9 cells; Ki= 5.7 &#181M for rat brain AChE).1,2Carbaryl administered at a dose of 30 mg/kg for 28 days in rats decreases the weight of spleen and thymus, proliferation of lymphocytes, and serum levels of IL-2, IFN-γ, IL-1β, and TNF-α, and increases the serum levels of IL-4 and IL-10.3It increases CaMKII, GAP-43, and tau protein levels in the hippocampus and tau levels in the cortex of mice 24 hours after administration of doses ranging from 0.5 to 20 mg/kg on postnatal day ten, whereas tau protein levels are decreased four months after administration with no change in CaMKII or GAP-43 compared with control mice. These effects occur at non-toxic doses where acetylcholinesterase is inhibited only during the first six hours following treatment. Formulations containing carbaryl have been used to control insects in agriculture.

1.Zhao, P., Wang, Y., and Jiang, H.Biochemical properties, expression profiles, and tissue localization of orthologous acetylcholinesterase-2 in the mosquito, Anopheles gambiaeInsect. Biochem. Mol. Biol.43(3)260-271(2013) 2.Hassan, A., Abdel-Hamid, F.M., and Bahig, M.R.E.Kinetics of inhibition of rat brain acetylcholinesterase by SevinZ. Naturforsch. B.22(5)505-507(1967) 3.Jorsaraei, S.G., Maliji, G., Azadmehr, A., et al.Immunotoxicity effects of carbaryl in vivo and in vitroEnviron. Toxicol. Pharmacol.38(3)838-844(2014)