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VAS2870
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VAS2870图片
CAS NO:722456-31-7
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
VAS2870 是一种NADPH氧化酶抑制剂。

产品描述

VAS2870 is an inhibitor of NADPH oxidase (NOX).

体外活性

VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits the proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells.VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Moreover, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM.

Cas No.

722456-31-7

分子式

C18H12N6OS

分子量

360.4

储存和溶解度

DMSO:83.3 mg/mL (231.14 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years