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GSK2795039
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK2795039图片
CAS NO:1415925-18-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
GSK2795039 是一种 NADPH 氧化酶 2 抑制剂,可抑制活性氧产生和 NADPH 消耗,同时可减少细胞凋亡。

产品描述

GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).

体外活性

GSK2795039 (25 μM; 24 hours) decreases the combinatory effect of FeSO4 and LPS-increased levels of apoptosis. It also reduced the presence of caspase-3-positive PC12 cells[2].

体内活性

GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) reduces activity in a murine model of acute pancreatitis. It also decreases the levels of serum amylase triggered by systemic injection of cerulein[1].

Cas No.

1415925-18-6

分子式

C23H26N6O2S

分子量

450.56

储存和溶解度

DMSO:31 mg/mL(68.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years