VoRasidenib 是口服具有活力的、脑渗透的突变体异柠檬酸脱氢酶 1 和 2 双重抑制剂。

Vorasidenib is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)

Vorsidenib reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg.

1644545-52-7

C14H13ClF6N6

414.74

PVM/MA;AG-881;PVM/MA共聚物

DMSO:125 mg/mL (301.39 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years