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Doxazosin-d8(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doxazosin-d8(hydrochloride)图片
CAS NO:1219803-95-8
包装与价格:
包装价格(元)
500 μg电议
1mg电议

产品介绍
An internal standard for the quantification of doxazosin
Cas No.1219803-95-8
别名甲磺酸多沙唑嗪杂质
Canonical SMILESCOC1=C(OC)C=C(C(N)=NC(N2C([2H])([2H])C([2H])([2H])N(C(C3COC(C=CC=C4)=C4O3)=O)C([2H])([2H])C2([2H])[2H])=N5)C5=C1.Cl
分子式C23H17D8N5O5.HCl
分子量496
溶解度Acetonitrile:Methanol (1:1): soluble,DMSO: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Doxazosin-d8is intended for use as an internal standard for the quantification of doxazosin by GC- or LC-MS. Doxazosin is a non-selective antagonist of α1-adrenergic receptors (α1-ARs; Kis = 3.16, 1, and 3.98 nM for α1A-, α1B-, and α1D-ARs, respectively).1It inhibits norepinephrine-induced contractions in isolated rat aortic rings and human prostate strips with pA2values of 8.8 and 8.2, respectively. Doxazosin inhibits phenylephrine-induced increases in blood pressure and prostatic pressure in anesthetized dogs (pA2= 7.5 for both). Formulations containing doxazosin have been used in the treatment of benign prostatic hyperplasia and hypertension.

1.Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al.Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studiesBr. J. Pharmacol.118(4)871-878(1996)