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Dronedarone-d6(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dronedarone-d6(hydrochloride)图片
CAS NO:1329809-23-5
包装:1mg
市场价:5216元

产品介绍
An internal standard for the quantification of dronedarone
Cas No.1329809-23-5
别名决奈达隆 D6
Canonical SMILESCCCCC1=C(C(C2=CC=C(OC([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCCC)CCCC)C=C2)=O)C3=CC(NS(C)(=O)=O)=CC=C3O1.Cl
分子式C31H38D6N2O5S.HCl
分子量599.3
溶解度Chloroform: Slightly soluble,Methanol: Slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dronedarone-d6is intended for use as an internal standard for the quantification of dronedarone by GC- or LC-MS. Dronedarone is an antiarrhythmic agent and a derivative of amiodarone .1,2It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively).2Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.3Formulations containing dronedarone have been used in the treatment of atrial fibrillation.

1.Sun, W., Sarma, J.S., and Singh, B.N.Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart: Comparison with amiodaroneCirculation100(22)2276-2281(1999) 2.Guillemare, E., Marion, A., Nisato, D., et al.Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cellsJ. Cardiovasc. Pharmacol.36(6)802-805(2000) 3.Saengklub, N., Limprasutr, V., Sawangkoon, S., et al.Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillationExp. Anim.66(3)251-258(2017)