| CAS NO: | 68252-19-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 68252-19-7 |
| 别名 | Cl-845 free base; (±)-Pirmenol |
| Canonical SMILES | OC(C1=NC=CC=C1)(C2=CC=CC=C2)CCCN3[C@H](C)CCC[C@@H]3C |
| 分子式 | C22H30N2O |
| 分子量 | 338.5 |
| 溶解度 | DMF: 2mg/mL,DMSO: 5mg/mL,Ethanol: 10mg/mL,Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pirmenol is a class I antiarrhythmic agent.1,2,3It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM.1Pirmenol (2.5 and 5 mg/kg) suppresses ouabain- or epinephrine-induced ventricular arrhythmias and aconitine-induced atrial arrhythmias in dogs.2,3 1.Sawanobori, T., Adaniya, H., Yamashita, S., et al.Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparationsJ. Cardiovasc. Pharmacol.16(6)975-983(1990) 2.Kaplan, H.R., Mertz, T.E., and Steffe, T.J.Preclinical pharmacology of pirmenolAm. J. Cardiol.59(16)2H-9H(1987) 3.Steffe, T.J., Mertz, T.E., Hastings, S.G., et al.CL-845 (pirmenol hydrochloride): A new orally effective long-acting antiarrhythmic agentJ. Pharmacol. Exp. Ther.214(1)50-57(1980) |
m.cnreagent.com