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Pirmenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pirmenol图片
CAS NO:68252-19-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A class I antiarrhythmic agent
Cas No.68252-19-7
别名Cl-845 free base; (±)-Pirmenol
Canonical SMILESOC(C1=NC=CC=C1)(C2=CC=CC=C2)CCCN3[C@H](C)CCC[C@@H]3C
分子式C22H30N2O
分子量338.5
溶解度DMF: 2mg/mL,DMSO: 5mg/mL,Ethanol: 10mg/mL,Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pirmenol is a class I antiarrhythmic agent.1,2,3It lengthens the final repolarization of action potentials in isolated rabbit ventricular myocytes and inhibits tachyarrhythmias induced by prolonged afterdepolarizations in isolated guinea pig papillary muscles when used at a concentration of 5 µM.1Pirmenol (2.5 and 5 mg/kg) suppresses ouabain- or epinephrine-induced ventricular arrhythmias and aconitine-induced atrial arrhythmias in dogs.2,3

1.Sawanobori, T., Adaniya, H., Yamashita, S., et al.Electrophysiologic and antiarrhythmic actions of pirmenol on rabbit and guinea pig cardiac preparationsJ. Cardiovasc. Pharmacol.16(6)975-983(1990) 2.Kaplan, H.R., Mertz, T.E., and Steffe, T.J.Preclinical pharmacology of pirmenolAm. J. Cardiol.59(16)2H-9H(1987) 3.Steffe, T.J., Mertz, T.E., Hastings, S.G., et al.CL-845 (pirmenol hydrochloride): A new orally effective long-acting antiarrhythmic agentJ. Pharmacol. Exp. Ther.214(1)50-57(1980)