| CAS NO: | 1219794-57-6 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 1219794-57-6 |
| 别名 | 甲苯磺丁脲 d9 |
| Canonical SMILES | CC1=CC=C(S(NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)(=O)=O)C=C1 |
| 分子式 | C12H9D9N2O3S |
| 分子量 | 279.4 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tolbutamide-d9is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50= 4.9 µM).1It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets.2In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin .3Formulations containing tolbutamide have been used in the treatment of type 2 diabetes. 1.Proks, P., Reimann, F., Green, N., et al.Sulfonylurea stimulation of insulin secretionDiabetes51(3)S368-S376(2002) 2.Ishiyama, N., Ravier, M.A., and Henquin, J.-C.Dual mechanism of the potentiation by glucose of insulin secretion induced by arginine and tolbutamide in mouse isletsAm. J. Physiol. Endocrinol. Metab.290(3)E540-E549(2006) 3.Rerup, C., and Tarding, F.Streptozotocin- and alloxan-diabetes in miceEur. J. Pharmacol.7(1)89-96(1969) |
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