TM5007 是纤溶酶原激活物抑制剂-1（PAI-1；IC50 为 29 uM）的强效抑制剂。

TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).

In vivo the most effective molecule (TM5007) inhibits coagulation in 2 models: a rat arteriovenous (AV) shunt model and a mouse model of ferric chloride-induced testicular artery thrombosis. It also prevents the fibrotic process initiated by bleomycin in mouse lung[1].

342595-05-5

C24H20N2O6S4

560.7

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years