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Lactisole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lactisole图片
CAS NO:150436-68-3
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品名称
2-(4-甲氧基苯氧基)丙酸
na-PMP
产品介绍
Lactisole 是葡萄糖感应受体的抑制剂。

产品描述

Lactisole is an inhibitor of the glucose-sensing receptor

体外活性

In MIN6 cells, in a dose-dependent manner, lactisole inhibited insulin secretion induced by sweeteners, acesulfame-K, sucralose and glycyrrhizin. The IC50 was ~4 mmol/l. Lactisole attenuated the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K but did not affect the elevation of intracellular cAMP concentration ([cAMP]c) induced by these sweeteners. Lactisole also inhibited the action of glucose in MIN6 cells. Thus, lactisole significantly reduced elevations of intracellular [NADH] and intracellular [ATP] induced by glucose, and also inhibited glucose-induced insulin secretion[1].

Cas No.

150436-68-3

分子式

C10H12NaO4

分子量

219.19

别名

2-(4-甲氧基苯氧基)丙酸;na-PMP

储存和溶解度

Ethanol:1 mg/mL
DMF:20 mg/mL
DMSO:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years