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Purpurogallin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Purpurogallin图片
CAS NO:569-77-7
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
红陪酚
红倍酚
产品介绍
Purpurogallin 是一种从栎属植物中提取的天然酚,具有显著的黄嘌呤氧化酶抑制作用,其IC50=0.2 μM,具有抗氧化和抗炎作用。

产品描述

Purpurogallin is a naturally phenol extracted from the plants of Quercus spp. It has effective xanthine oxidase inhibitory activity (IC50: 0.2 μM). Purpurogallin also has antioxidant and anti-inflammatory effects.

体外活性

Purpurogallin (100 μM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells. Purpurogallin (50 or 100 μM; 7 or 25 hours; BV2 murine microglial cells) treatment decreases the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells[1].

体内活性

By the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression, Purpurogallin (100-400?μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect [2].

Cas No.

569-77-7

分子式

C11H8O5

分子量

220.18

别名

红陪酚;红倍酚

储存和溶解度

DMSO:125 mg/mL (567.72 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years