ML265 是选择性的丙酮酸激酶 M2 (pyruvate kinase M2; PKM2) 激活剂，AC50=92 nM，对 PKM1，PKL 和 PKR 作用较小或没有作用。

ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .

At 50 mg/kg, ML-265 has been shown to reduce tumor size, weight, and occurrence in mice bearing H1299 cell xenografts in a model of human non-small cell lung carcinoma[1]

1221186-53-3

C17H16N4O2S2

372.46

ML265

DMSO:50 mg/mL (134.24 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years