Mitapivat 是口服具有活性的变构丙酮酸激酶 (pyruvate kinase) 激活剂，其AC50=20 nM。它在广泛的 PKLR 基因型中增加酶活性、蛋白质稳定性和 ATP 水平。它有潜在的恢复 PK 缺乏的糖酵解途径活性的作用。

Mitapivat, also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.

1260075-17-9

C24H26N4O3S

450.56

PKR-IN-1

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years