Eflornithine hydrochloride Monohydrate 是一种特异性的、不可逆的酶鸟氨酸脱羧酶抑制剂。它可用于研究非洲锥虫病和女性面部毛发过度生长。
产品描述
Eflornithine hydrochloride is a specific, irreversible inhibitor of ornithine decarboxylase.
体外活性
When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur[1].
体内活性
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[2]. Eflornithine 15% cream is superior to a placebo in reducing hair growth in subjects with excessive, unwanted facial hair. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[3]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[4]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[5].
细胞实验
BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference)
Cas No.
96020-91-6
分子式
C6H15ClF2N2O3
分子量
236.64
别名
Eflornithine hydrochloride Monohydrate;依氟鸟氨酸盐酸盐一水合物;Difluoromethylornithine hydrochloride hydrate;RMI-71782 hydrochloride hydrate;Eflornithine hydrochloride;α-difluoromethylornithine hydrochloride hydrate;DFMO hydrochloride hydrate;MDL-71782 hydrochloride hydrate
储存和溶解度
DMSO:2.5 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years