LovaSTATin是一种 HMG-CoA 还原酶抑制剂，用于降低胆固醇。

Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.

Lovastatin is an inactive lactone that is hydrolyzed in the liver to an active f3-hydroxyacid form. This principal metabolite is the inhibitor of the enzyme HMG-CoA reductase. The Ki is 1 nM. Lovastatin and its β-hydroxyacid metabolite are highly bound to human plasma proteins. Lovastatin crosses the blood-brain and placental barriers[6]. Lovastatin produces a profound reduction of apolipoprotein-B-containing lipoproteins, especially LDL cholesterol and, to a lesser extent, plasma triglycerides, and a small increase in HDL cholesterol[7].

Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2].

75330-75-5

C24H36O5

404.54

Mevinolin;洛伐他汀;MK-803

DMSO:40.5 mg/mL (100 mM)
Ethanol:20.2 mg/mL (50 mM)),with gentle warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years