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SB 204990
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB 204990图片
CAS NO:154566-12-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
SB 204990是一种有效的、特异性ATP柠檬酸裂解酶抑制剂。

产品描述

SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.

体外活性

SB204990 treatment leads to a reduction in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels [1].

体内活性

SB 204990 is absorbed into the systemic circulation when administered orally to rats. SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats when administered in the diet (0.05-0.25%, w/w) for 1 week. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels [2].

Cas No.

154566-12-8

分子式

C18H22Cl2O5

分子量

389.27

储存和溶解度

DMSO:100 mg/mL (256.89 mM)
H2O:10 mg/mL (25.69 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years