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BMS-779788
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS-779788图片
CAS NO:918348-67-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
XL 652
XL-652
BMS-788
XL652
EXEL04286652
产品介绍
XL652 是一种LXR的部分激动剂,能够作用于 LXRα (IC50:68 μM) 和 LXRβ (IC50:14 μM)。

产品描述

BMS-779788 is an LXRα/β partial agonist (IC50: 68/14 nM).

体外活性

BMS-779788 can effectively induce ATP binding transporters ABCA1 and ABCG1 in the human whole blood (EC50: 1.2 μM).

体内活性

BMS-779788 has an inducted effect of LXR target genes in blood in vivo (EC50: 610 nM). In elevating plasma triglyceride and LDL cholesterol, BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 respectively[1]. In mice, BMS-779788 displayed peripheral induction of ABCA1 at 3 and 10mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2].

Cas No.

918348-67-1

分子式

C28H29ClN2O3S

分子量

509.06

别名

XL 652;XL-652;BMS-788;XL652;EXEL04286652

储存和溶解度

DMSO:31 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years