4-Methylpyrazole 是细胞色素 P450 (CYP2E1) 抑制剂。它是乙醇脱氢酶 (alcohol Dehydrogenase) 竞争性抑制剂。它能够阻断甲醇和乙二醇进一步转化为有毒代谢产物。它具有成为乙二醇或甲醇中毒的解毒剂的潜力。

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

7554-65-6

C4H6N2

82.106

甲吡唑;4-Methylpyrazole;4-甲基吡唑;Antizol;Antizol-Vet

H2O:100 mg/mL (1218.03 mM),Need ultrasonic
DMSO:100 mg/mL (1218.03 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years