DG051 是有效的白三烯 A4 水解酶抑制剂，IC50=47 nM。

DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).

DG051 is a potent inhibitor of LTA4H aminopeptidase activity against L-alanine p-nitroanilide (IC50: 72 nM). DG051 inhibits human whole blood (HWB) with IC50 of 37 nM [1]. DG-051 is an LTA4H inhibitor, currently in Phase II clinical development for the prevention of heart attack [2].

929915-58-2

C21H25Cl2NO4

426.33

DMSO:317 mg/mL (743.56 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years