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Puromycin aminonucleoside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Puromycin aminonucleoside图片
CAS NO:58-60-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
维生素E醋酸酯
NSC 3056
产品介绍
Puromycin aminonucleoside 是一种氨基核苷类抗生素,是嘌呤霉素类似物。它可逆抑制二肽基肽酶和胞浆丙氨酸氨基肽酶。它通过以氧化应激依赖性方式调节 ZO-1 来增加足细胞通透性。它诱导细胞凋亡 。

产品描述

Puromycin aminonucleoside increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.

体外活性

Puromycin aminonucleoside -induced podocyte apoptosis is p53 dependent. Puromycin aminonucleoside causes podocyte apoptosis in a time-dependent manner. The IC50 values for PMAT-expressing and vector-transfected cells are 48.9 and 122.1 μM, respectively, suggesting expression of PMAT-enhanced cell sensitivity to Puromycin aminonucleoside. Puromycin aminonucleoside uptake in PMAT-expressing cells is fourfold higher at pH 6.6 than that at pH 7.4. Puromycin aminonucleoside (30 μg/mL) markedly enhances p53 protein levels in podocytes. Puromycin aminonucleoside (250 μM) is toxic to both PMAT-expressing and vector-transfected cells [2][4].

体内活性

Rats given Puromycin aminonucleoside (100 mg/kg, s.c.) gain less weight and their serum creatinine levels are higher than the control rats. The number of podocytes per glomerulus is 95.5±17.6 in the control rats, 90.7 on Day 4 in Puromycin aminonucleoside (8 mg/100 g, i.v.)-treated nephrosis rats. The amount of nephrin per glomerulus in control rats is 1.02±0.11 fmol and those in Puromycin aminonucleoside nephrosis rats are reduced to 0.46±0.06 fmol and 0.35±0.04 fmol on Day 4 and Day 7. The nephrin amount per podocyte is significantly decreased association with the development of proteinuria in Puromycin aminonucleoside nephrosis rats [5][6].

Cas No.

58-60-6

分子式

C12H18N6O3

分子量

294.31

别名

维生素E醋酸酯;NSC 3056

储存和溶解度

H2O:33.33 mg/mL (113.25 mM),Need ultrasonic
DMSO:31 mg/mL(105.33 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years